SCAN-B MutationExplorer

MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 # Genes with

Gene Ontology (GO) annotations related to this gene include magnesium ion binding and inositol tetrakisphosphate 1-kinase activity. UniProtKB/Swiss-Prot Summary for ITPK1 Gene Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Itpka gene

ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers: Journal of Thoracic Oncology 23 Oct 2018 were shown for ITPKA (p = 0.02) and angiogenin (p = 0.113). Conclusions In this study growth pattern-specific gene signatures in pulmonary Standard name, ST_ADRENERGIC. Systematic name, M19043. Brief description, Adrenergic Pathway. Full description or abstract. Collection, C2: curated gene Wnt/Ca2+/cyclic GMP signaling.

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Cited in 1 publications. proteins (a major isoform for each protein encoding gene). Create a map of tibodies.

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RRO Use the search box at the top right of all Ensembl views to search for a gene, phenotype, sequence Gene-based displays Gene: ITPKA ENSG00000137825. 24 May 2016 In silico analysis of The Cancer Genome Atlas data set was also performed. Results. Inositol-trisphosphate 3-kinase A gene (ITPKA), a kinase 5 Jan 2021 In contrast, ITPKA is expressed primarily in neurons, while ITPKC expression is restricted to glia (27).

The activity of the inositol Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23. This plasmid is available through Addgene. Gene: ITPKA - ENSCAFG00000009562 - Canis lupus familiaris (dog) General information.
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Design This Rabbit polyclonal antibody raised against recombinant ITPKA.Hundratusentals antikroppar är tillgängliga hos VWR. Hitta din antikropp genom att selektera på IP3KA siRNA (h), shRNA and Lentiviral Particle Gene Silencers are designed to knockdown gene expression of human IP3KA. Cited in 1 publications. proteins (a major isoform for each protein encoding gene). Create a map of tibodies. Number of genes/antibodies included per new release ITPKA (lat.

Itpka inositol 1,4,5-trisphosphate 3-kinase A [ (house mouse)] Gene ID: 228550 , updated on 22-Nov-2020 Gene name: ITPKA (HGNC Symbol) Synonyms: IP3-3KA, IP3KA: Description: Inositol-trisphosphate 3-kinase A (HGNC Symbol) Chromosome: 15: Cytoband: q15.1: Chromosome location (bp) 41493393 - 41503551: Number of transcripts i Itpka - Inositol-trisphosphate 3-kinase A - Rattus norvegicus (Rat) - Itpka gene & protein UniProtKB - P17105 (IP3KA_RAT) ITPKA (inositol-trisphosphate 3-kinase A) Since ITPKA gene body methylation occurs early in tumor development, it could serve as biomarker for early detection of lung cancer. Detailed mechanistic studies revealed that down-regulation of ITPKA in lung adenocarcinoma cancers reduced both, tumor growth and metastasis. Biological context of ITPKA. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization.
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REFERENCES Erneux, C., Roeckel, N., Takazawa, K., Mailleux, P., Vassart, G., Mattei, M. G. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. Functional Associations.

SCAN-B MutationExplorer

Predicted to be involved in inositol phosphate biosynthetic process and phosphatidylinositol phosphorylation. Predicted to localize to cytoplasm and nucleus. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). ITPKA is expressed in a broad range of tumor types but shows limited expression in normal cells. In lung and breast cancer expression of ITPKA is stimulated by gene body methylation which increases with increasing malignancy of these tumors but is not detectable in the corresponding normal tissues. Gene: Itpka - ENSRNOG00000005284 - Rattus norvegicus (rat) General information. Ensembl ID: ENSRNOG00000005284: Name: Itpka: Description RefSeq summary [ITPKA] Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6.

ITPKA Gene inositol-trisphosphate 3-kinase A Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling.